Most common of the bleeding disorders
- 1:100
vWF
- needed for platelet adhesion and platelet-platelet interactions
- also carrier for factor VIII / protects it from rapid breakdown
Gene on chromosome 12
1. Reduced production VWF
Patient
Advanced age
Immunosuppression - steroids / Rheumatoid / DM
Malnutrition - Lymphocyte count / Transferrin / Albumin
Vascular disease
Obesity
Poor skin i.e. psoriasis
Previous infection in joint
Infection elsewhere - i.e. UTi
Prolonged hospital admission
Revision surgery
Operative Factors
Preoperative
Pseudogout
- Calcium Pyrophosphate Dihydrate (CPPD) crystals
- inflammatory arthritis of older individuals