cryoprecipitate

Blood Products

Goal

 

Ultimate goal of blood management is to AVOID allogenic blood transfusion

 

Problems

 

Increased infection rate

- demonstrated in THR

- decreased killer T cells

Increased risk disease transmission

Increased risk transfusion reaction

Increased post-op fever and antibiotic requirements

Increased cost

Von Willebrand's Disease

Incidence

 

Most common of the bleeding disorders

- 1:100

 

Function

 

vWF            

- needed for platelet adhesion and platelet-platelet interactions

- also carrier for factor VIII / protects it from rapid breakdown

 

Aetiology

 

Gene on chromosome 12

1.  Reduced production VWF