malignant fibrous histiocytoma

Undifferentiated Pleomorphic Sarcoma

Definition

 

Malignant Fibrous Histiocytoma

 

Characterised by heterogenous population of pleomorphic spindle cells

- organised in a characteristic storiform or "starry night" pattern

 

Cell of origin unknown 

- primitive mesenchymal cell

- allowing both features of a macrophage (hence histiocyte)

- and collagen producing cell (hence fibroblast)

 

Epidemiology