pepper pot skull

Multiple Myeloma

Definition

 

Uncontrolled proliferation of single clone of plasma cells

 

Epidemiology

 

Most common malignant tumour of bone

 

Age 50-60

 

2-3 / 100 000

 

Pathology

 

Highly differentiated B lymphocytes

- associated with abnormality of protein synthesis

 

Usually bone marrow of entire skeleton involved