Blood Products



Ultimate goal of blood management is to AVOID allogenic blood transfusion




Increased infection rate

- demonstrated in THR

- decreased killer T cells

Increased risk disease transmission

Increased risk transfusion reaction

Increased post-op fever and antibiotic requirements

Increased cost


Aim of Coagulation


To produce sufficient thrombin to rapidly convert soluble fibrinogen into insoluble mass of fibrin


Coagulation cascade must be localised & limited to site of tissue injury


Three phases


1.  Immediate Control of Blood Loss


Vascular Phase

- damage to blood vessel triggers reflex vasoconstriction


Platelet phase